Fedora has always been a prime breeding ground for innovation, this will continue. Fedora will become known among coders, hackers, and scholars as the OS of choice for their works.
Coders will see a few developer specific features added in the form of custom re-spins and new tools for more integrated ways of collaborating. They will find new ways to work with each other far outside of email. Fedora as an operating system will slowly become a gateway into online collaboration and into Fedora (and other OSS) contribution. I count roughly 25 source control repos being shared on fedorapeople.org already (launched just 2 months ago). Most people don't even know that git, hg, bzr, svn and cvs are installed on the box.
Hackers will be very compelled to use Fedora for it's re-spin and architecture support. dgilmore, spot and company have been hard at work to bring secondary architectures online. I predict people will see Fedora making its way onto a wide variety of exotic hardware. Secondary architecture support isn't even completed yet and there is already confirmed interest from people wanting to build Fedora for arm, ia64, sparc, s390, and alpha. This isn't people wanting Fedora for those archs, these are people wanting and willing to build it themselves. Hackers will start re-spinning their own official and non official Fedora spins including custom builds like Mythdora (Mythtv version of Fedora) and other builds that I can't even imagine right now. I predict people will be installing Fedora onto their favorite $GAMECONSOLE as well as more embedded devices like their linksys router and toaster. Why? Because we've made our process as transparent as possible and the tools we use encourage it, making it easy.
Scholars will continue to look to Fedora as a completely free operating system where brand new technologies are always available. OLPC will prove a poster child in how to customize Fedora for specific use in education. I'm confident Fedora will make its way into the classrooms it just needs a leader who's willing do the work to talk to universities to get it done (this may be closer then I know :). Scholarly technophiles will learn to look to Fedora to see what most operating systems will be like in two years. They, and others, will join Fedora making us better because they realize that as a user who's willing to contribute,they not only have a stake in the outcome of a release but can ensure that they've help make Fedora all it can be.
1) Fedora will become extremely popular in non-english speaking places. http://translate.fedoraproject.org/ will see to this.
2) In the near future speaking English will not be a requirement to join Fedora (I'm going to personally try to see to this)
3) Someone will yet again see the value in basing another enterprise version of their software off of Fedora :)
4) Fedora will be even more available in other countries. Very soon we're getting our first Chinese mirror!
5) Integration, collaboration and just being online will be easier than ever
6) Fedora as a community will grow at a faster rate then Fedora as an operating system from where it is right now.
6) Ubuntu will be called the new Windows. Fedora will be called the new Linux and I can't wait.